-
NYU Dataset
Novel pH Modulation of Lysosomes Through β2-Adrenergic Regulation of ClC-7 in Alzheimer’s Disease
- Authors
- Ju-Hyun LeeDevin M. WolfeSandipkumar DarjiMary Kate McBrayer5 more author(s)...
- Description
Lysosomal dysfunction plays a key role in the pathogenesis of Alzheimer’s disease (AD) and Parkinson’s disease (PD). In early onset of AD, there is loss of Presenilin-1 (PSEN1) function. The loss of PSEN1 function impedes ER to lysosome delivery of chloride channel-7 (ClC-7). In murine blastocysts with different PSEN1 genotypes, isoproterenol and related β2-adrenergic agonists was used to reverse lysosomal...
- Subject
-
GenomicsNeuroscience
- Access Rights
- Free to All
-
NYU Dataset
An eIF3d-Dependent Switch Regulates Human Cytomegalovirus Replication
- Authors
- Letitia ThompsonDaniel P. DepledgeHannah M. BurgessIan Mohr
- Description
Gene expression rapidly responds to physiological stress like virus infection in part via the control of mRNA translation. However, how translation of virus and host mRNAs are regulated during infection stress remains unknown. This study showed that protein synthesis in human cytomegalovirus (HCMV)-infected cells unexpectedly becomes progressively reliant upon eIF3d, which is a mRNA cap-binding protein...
- Subject
-
Genomics
- Access Rights
- Free to All
-
NYU Dataset
Fluoride Exposure Alters Calcium Signaling and Mitochondrial Function in Enamel Cells
- Authors
- Francisco J. AulestiaJohnny GroelingGuilherme H. Souza BomfimVeronica Costiniti8 more author(s)...
- Description
Fluoride is a naturally occurring mineral that helps build strong teeth and prevent cavities. However, excessive fluoride intake causes dental fluorosis, which are enamel defects that can increase the risk of tooth decay. This study examined the effects of fluoride exposure in enamel cells to assess its impact on calcium signaling. For their investigation, they isolated primary EO cells from Sprague...
- Subject
-
Genomics
- Access Rights
- Free to All
